There are so many products available on the market one can use to boost their metabolic process, and get the best out of their workout routine. However, if among medical substances there is one that should be singled out as one of the most controversial, then growth hormone would certainly be one of the competitors for that place.
Well, not the whole hormone, but one particular fragment, to be exact, HGH Frag 176-191 Peptide. In order to learn more about this fragment, it’s important to understand the whole picture, therefore we start by explaining more about the growth hormone.
Where is a growth hormone produced?
Growth hormone (HGH) is produced in the anterior lobe of the pituitary gland and is also called somatotropin. Growth hormone release is regulated by the interaction of the hormones somatostatin and somatocrinin. Somatostatin inhibits growth hormone release, while somatotropin releases growth hormone. In addition to these two, increased growth hormone release is caused by external stimuli such as starvation, hypoglycemia, muscle activity, trauma, stress, etc.
Once released from the pituitary gland, it remains active in the bloodstream for only a few minutes, but that is enough time for the liver to convert it into growth factors, the most important of which are insulin-like growth factor 1 (IGF-1), which enhances the anabolic environment in the body.
Since it is also in charge of how we grow, you are already aware of how its levels drop with age. After the age of 30, that level drops by 25% in each subsequent decade, so at the age of 60, you have only 25% of the amount of hormone you had in your prime (the twenties). As scientists assume, if the level did not decrease with age, the lifespan of a person would be about 140 years, we would be several centimeters taller and we would have significantly more muscles.
Now, let’s explain more about the particular fragment, in charge of building muscles.
What Exactly is HGH-Frag 176-191?
HGH-Frag is Human Growth Hormone that has been fractionated. HGH’s 191-amino-acid sequence is shortened by 16 of these amino acids. C39H60N8O13 is the molecular formula for the peptide.
However, the HGH-Frag operates by a mechanism quite distinct from that of HGH. Since HGH fragments are derived from Growth Hormone, logic dictates that they function similarly. The reality, though, is that the reply is negative.
Because it lacks the last 191 amino acids in its parent GH, HGH-Frag cannot attach to Growth Hormone Receptors (GHR). Therefore, it cannot work as anabolic as GH does via transcribing IGF-1 production.
What is the function of HGH-Frag 176-191?
The lipolytic effects of GH have been preserved. This preservation has led to the HGH-FRAG peptide being the medication of choice for regulating lipid metabolism.
The HGH-FRAG Mechanism of Action
HGH-FRAG method of action has been the target of several criticisms and remains poorly understood. But there are three key areas where HGH-FRAG performed very well. Let’s investigate these scientifically supported techniques to learn more about the widespread acceptance of HGH-FRAG 176-191.
Unlike its parent biomolecule, Growth hormone, HGH-FRAG is missing some functional characteristics. Instead, it needed only one remarkable quality: lipolysis. When HGH-FRAG 176-191 was administered to obese mice, a rise in beta-3 adrenergic receptor development was seen in adipose tissue. These receptors mediate thermogenesis in skeletal muscle and have been linked to a role in fat mobilization and utilization in adipose tissue.
Also, studies show that HGH-FRAG therapy may significantly reduce weight growth (by around 50%) in obese mice after only three weeks of treatment. Only obese/overweight mice benefited from HGH-FRAG 176-191 treatment. In a mouse of medium weight, it had no appreciable effect on body composition.
HGH-C-FRAG’s terminal ability to generate hypoglycemia provides a second potential mode of action. So, scientists determined whether the HGH fragments retained their hypoglycemic properties.
The numbers 176-191 are one such chunk. The peptide fragment has been shown to have the capacity to lower blood glucose levels, making it a viable option for treating prediabetes and type 2 diabetes mellitus (DMT2). However, significantly more meta-analysis and clinical studies are required to declare any of the pathways above with solid core evidence.
More rigorous studies are now being conducted to understand further the potential effects of HGH-FRAG 176-191 on cartilage regeneration and growth. Researchers found that injecting rabbits with HGH-FRAG and Hyaluronic acid significantly increased cartilage development.
More reliable research is needed before the concept of employing HGH-FRAG 176-191 to treat osteoarthritis and reduce the need for surgery can be fully developed, according to scientists.
There are a couple of ways one can induce the release of this hormone naturally…
Three important factors affect this hormone’s growth levels. That is:
- physical activity (strength training)
Very simply, the more you exercise, the more of this hormone your body will produce. The intense training that consumes large amounts of energy and longer periods of physical exhaustion through training is the key to the production of greater amounts of this hormone. It is because these catabolic states require additional protein synthesis, and in cases of energy consumption, increased fat metabolism is required to replace empty glycogen stores.
Also, it is released from the pituitary gland during sleep. As much as 75% of the total daily amount of secreted growth hormone is produced during sleep, especially in the REM phase of sleep. Studies confirm that it is at its highest level during deep sleep, so it is recommended to sleep at least 7 hours.
A balanced diet that is rich in all important nutrients and maintains health and weight also maintains high levels of growth hormones.
Advantages of Human Growth Hormone-Fragment
Clinical studies were conducted repeatedly on HGH-FRAG before making it available to the public. Inhibiting lipolysis, increasing energy, bolstering and building muscle mass, and significantly reducing obesity are just some of the research-backed advantages of HGH-FRAG 176-191. HGH-FRAG decreases the risk of developing cardiometabolic illnesses like Type 2 Diabetes Mellitus due to its ability to control blood glucose levels (T2DM).
Some studies suggest that it does not affect IGF-1 serum levels or have any other noticeable effects on the body. The musculoskeletal system may be influenced by its usage to boost bone density and speed up muscle repair. Check this website if you are a researcher and you are looking for more information about peptides.